Importantly, high MMP-14 expression was significantly associated with worse overall survival (OS) (p = 0.0065, HR 5.01, 9% CI 1.56–16.14) and disease-free survival (DFS) (p=0.00035, HR 5.78, 95% CI 2.23–15.01) of ACC patients (Figs. 1C – 1D). The gene discussed is MMP14; the disease is adrenal cortex carcinoma.