Inhibiting PAK1/2 with FRAX597 and FRAX486 or MTOR with AZD-8055 reduced RAS expression in MM cell lines within 24 to 48 hours, as demonstrated by immunoblot (Fig. 6D) and FACS analysis on cells ectopically expressing mNG-KRASG12D (Fig. S6B–C). This evidence concerns the gene PAK1 and Miyoshi myopathy.