Consistent with our findings in MM, we observed that LZTR1 knockdown (Fig. 4M) and ectopic expression of DN PP1C (Fig. S4J) increased RAS expression, while PPP1R2 knockdown (Fig. S4K) reduced RAS in the GCB DLBCL cell lines WILL2, WSU FSCCL, and Toledo, which all express mutant KRASG13D. This evidence concerns the gene LZTR1 and diffuse large B-cell lymphoma.