LRRK2 and Parkinson disease: PD-linked mutations segregate within the kinase domain (e.g. G2019S) and the Roc-COR tandem domain (e.g. R1441C, Y1699C) of LRRK2 and increase phosphorylation towards a subset of Rab GTPases including Rab8a and Rab1030,31 disrupting endolysosomal dynamics22–25.