Broadly, these late-diverging genes represented core processes disrupted in HD, encoding proteins regulating synaptic transmission (Vat1l, Sik2), lipid signaling (Flot2), glycolysis (Pfkfb3), and neuronal excitability (Ano2, Ano4, Cacng4;Fig. 2e). This evidence concerns the gene ANO2 and Huntington disease.