Broadly, these late-diverging genes represented core processes disrupted in HD, encoding proteins regulating synaptic transmission (Vat1l, Sik2), lipid signaling (Flot2), glycolysis (Pfkfb3), and neuronal excitability (Ano2, Ano4, Cacng4;Fig. 2e). The gene discussed is SIK2; the disease is Huntington disease.