These included TFs associated with HD relevant modules: SPN-M4 (Foxo1, Npas2, Smad4, Egr2), SPN-M6 (Klf12, Mlxip, Wt1), and SPN-M12 (Bach1, Shox2, Neurod2) (Fig. 5c-d), all genotype- and age-dependent modules enriched in CAG repeat length-dependent genes. This evidence concerns the gene SHOX2 and Huntington disease.