Emerging evidence has shown that pro-inflammatory cytokines, such as interleukin (IL)-6 and IL-8, are particularly promising as serum biomarkers for PSCID, as their levels show a positive trend among those experiencing cognitive decline (Rafnsson et al., 2007; Rani et al., 2022; Weaver et al., 2002). The gene discussed is CXCL8; the disease is Mental deterioration.