Previous meta-analyses on SGLT2-Is (Saad et al., 2017), GLP1-RAs (Darsalia et al., 2015; Mahmouda et al., 2017), and DPP4-Is (Darsalia et al., 2015; Savaresea et al., 2016; Mahmouda et al., 2017; Rehman et al., 2017; Xu et al., 2017) yielded discordant results for the risk of MACEs and stroke. The gene discussed is DPP4; the disease is Stroke.