In this study we evaluated 3 key aspects pertaining to patients undergoing TAVI for severe AS from the perspective of RPT: 1) renal function, 2) increased troponin levels and PMI development, and 3) short-term outcomes of PMI over 30 days (Central Illustration):1.A significant and negative correlation was found between baseline eGFR and cTnT levels in the entire patient group (P < 0.0001) (Fig. 2). The gene discussed is TNNT2; the disease is aortic valve stenosis.