Detection of urinary podocytes has been performed with specific anti- PODXL or Wilms tumor 1 antibodies.28, 29, 30, 31, 32 Achenbach et al. and others have shown that parietal epithelial cells, which share developmental origins with podocytes, also express PODXL and Wilms tumor 1 and are readily excreted into the urine during active glomerular disease.33, 34, 35 In addition, Hara et al.36 showed that urinary PODXL may not originate from detached podocytes, but from membrane shedding in response to podocyte injury. Here, PODXL is linked to glomerular disorder.