AKT1 and neoplasm: Moreover, miRNAs regulate the expression of numerous genes and pathways, and alterations in their expression may activate oncogenes or silence tumor suppressors, including the phosphoinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/AKT/mTOR), mitogen-activated protein kinase (MAPK), and Wnt/β-catenin pathways [16], [17], [18], [19], [20].