SERPIND1 and neurodegenerative disease: Proteomic profiling of CSF identified numerous differentially abundant proteins (FDR <.05) between CD38KO and WT mice, Notably, several members of the serpin family (Serpind1, Serpina1d, and Serpina3k), which are established markers of neuroinflammation and astrocyte reactivity in aging and neurodegenerative diseases, were significantly downregulated in CD38KO CSF.