To examine the mechanistic role of FTH1 in ARDS, we generated a murine model of FTH1 depletion in myeloid cells using Cre-Lox recombination, placing Fth1 under the control of the Lyz2 promoter (Fth1ΔLysM, Supplementary Figure 4A). The gene discussed is FTH1; the disease is acute respiratory distress syndrome.