10% (1/10) of prostate normal tissue cores, 68.6% (33/49) of hyperplasia, 60% (3/5) of tumor adjacent tissues, 97.6% (41/42) of PIN, and 81% (113/138) prostate adenocarcinoma tissue cores were positive for SKP2 (Table 1). This evidence concerns the gene SKP2 and prostate intraepithelial neoplasia.