SKP2 and adenocarcinoma: SKP2 is sparsely overexpressed in hyperplasia, tumor adjacent tissues, PIN and adenocarcinoma with average percentage of positive SKP2 staining cells per core of 0.34%, 0.46%, 1.16%, and 2.43%, respectively, compared to that of normal prostate tissues (0.12%) (Fig. 7A & B) (Ps < 0.05).