CD4 and neoplasm: Our data showed that C06c CD4 Tfh:IGFL2 cells often co-localise with naive and memory B cells and dendritic cells (Figure 4C; Extended Data Fig. 4B-C); C06c IGFL2+ Tfh cells were significantly enriched proximal to CCR7+ CD4 T-cells, B cells and LAMP3+ DCs (mReg: DCs71￼), antigen-elicited DC found to engage and regulate tumor reactive T-cells72￼ (Extended Data Fig.