HMGB1 and laryngotracheoesophageal cleft: A cluster of cytokines grouped in module 2 showed the highest odds ratio of positive association with LC, with significant enrichment of cytokines such as IL-11, LIF, Eotaxin-3, IL-23, IFN-β, and HMGB-1, which were closely correlated with LC outcome (Fig. 5c).