At diagnosis, the patient’s serum tumor markers-pro-gastrin-releasing peptide (pro-GRP) and neuron-specific enolase (NSE)-were elevated at 2,580 pg/mL (normal levels: < 81 pg/mL) and 34 ng/mL (normal levels: < 15 ng/mL), respectively. The gene discussed is ENO2; the disease is neoplasm.