Modern HTAD gene panels now include more than 30 genes known to confer risk for thoracic aortic aneurysm and dissection, encompassing extracellular matrix genes (e.g., FBN1, COL3A1), smooth muscle contractile protein genes (e.g., ACTA2, MYH11, MYLK), and TGF-β signaling genes (e.g., TGFBR1, TGFBR2, SMAD3) [7]. Here, FBN1 is linked to thoracic aortic aneurysm.