IDH2 and neoplasm: In the univariate model, age ≥65 years (HR: 2.38; 95% CI: 1.63-3.48; p < 0.001), Karnofsky index <70% (HR: 2.57; 95% CI: 1.56-4.24; p < 0.001), presence of seizures (HR: 0.55; 95% CI: 0.38-0.81; p = 0.002), IDH-wt versus IDH-m status (HR: 0.19; 95% CI: 0.11-0.33; p < 0.001), tumor location (frontal lobe vs. other sites) (HR: 0.47; 95% CI: 0.31-0.71; p < 0.001), and type of procedure (biopsy vs. surgery) (HR: 2.56; 95% CI: 1.64-3.98; p < 0.001) showed significant associations with survival.