IDH2 and neoplasm: In the multivariate model, independent predictors of OS included age ≥65 years (HR: 1.76; 95% CI: 1.16-2.67; p = 0.008), Karnofsky index ≥70% (HR: 2.02; 95% CI: 1.18-3.47; p = 0.01), IDH-wt versus IDH-m status (HR: 0.25; 95% CI: 0.14-0.45; p < 0.001), tumor location (frontal lobe vs. other regions) (HR: 0.61; 95% CI: 0.39-0.97; p = 0.039), and procedure type (biopsy vs. surgery) (HR: 2.04; 95% CI: 1.26-3.31; p = 0.004).