In a study involving 788 ischemic stroke patients, brain natriuretic peptide (BNP) levels were significantly associated with 90-day post-stroke mortality, while another study found BNP to be independently correlated with functional outcomes at 90 days (Hellwig et al., 2021; Hatab et al., 2023; Nigro et al., 2014). The gene discussed is NPPB; the disease is ischemic stroke.