It mediates high-affinity binding of ApoE-containing lipoproteins to low-density lipoprotein receptors (LDL-R) and LDL-R-related protein-1, facilitating the clearance of triglyceride-rich lipoproteins from circulation and conferring protection from atherosclerosis (Sofat et al., 2016). Here, LDLR is linked to atherosclerosis.