Whereas, some studies have demonstrated an association between low ApoE plasma concentration with stroke (Mooijaart et al., 2006; van Vliet et al., 2007; Corsetti et al., 2012), others have not or have even demonstrated an opposite association, with higher circulating concentration of ApoE associated with a higher risk of incident stroke (Mooijaart et al., 2006). Here, APOE is linked to stroke disorder.