In addition to our previously identified common COL4A3 p.Asp326Tyr variant (rs55703767; P = 5.0 × 10−8), a novel, rare (MAF: 0.4%) EXD3 p.Asp555Asn variant (rs200080727 C/T, P = 4.5 × 10−9) was associated with the combined CKD + DKD phenotype, that is, cases with albuminuria (AER ≥ 20 μg/min or equivalent) and eGFR < 45 ml/min per 1.73 m2 (Table 1, Figure 2, Supplementary Figures S2 and S3). Here, COL4A3 is linked to chronic kidney disease.