Furthermore, a genome sequencing study of 76 sibling pairs with T1D suggested involvement of protein kinases in DKD,17 and an exome and genome sequencing study including 1064 unrelated individuals with T1D identified a missense variant in the LTA gene, encoding for tumor necrosis factor-β, associated with lower tumor necrosis factor receptor levels and reduced risk of DKD.18 This evidence concerns the gene WEE1 and type 1 diabetes mellitus.