,48 It has been reported that Musclin can inhibit the glucose uptake process of myoblasts induced by insulin,6 which indicates that Musclin, a muscle secretion factor, has complex regulatory characteristics in the occurrence and development of T2DM and complications: on the one hand, it is a “pathological factor” directly involved in the occurrence of diseases, on the other hand, it may be a “compensatory marker” reflecting metabolic disorders. This evidence concerns the gene INS and metabolic disease.