Clinical studies have found that there is a complex correlation between the circulating level of Musclin and the course of hypertension: the circulating level of Musclin in patients undergoing transcatheter aortic valve implantation is low, often accompanied by weakness, low albumin, hypertension and stroke history62; The plasma Musclin level in patients with essential hypertension is generally lower than that in healthy people, but it is significantly higher in patients with hypertension-related stroke.11 The gene discussed is OSTN; the disease is Hypertension.