TMT1A and neoplasm: Figure 3D shows the correlation between TMT1A and the 14 functional states described in STAR Methods. These results indicate that TMT1A was negatively correlated with these pathways in LUAD. SsGSEA was used to analyze the correlation between TMT1A expression and pathway score. TMT1A expression positively correlated with extracellular matrix (ECM)-related genes (p < 0.0001) but negatively correlated with DNA replication, tumor proliferation signature, and the G2M checkpoint (p < 0.0001, Figure 3E), which were consistent with the findings from GO BP and KEGG analysis.