For instance, in EGFR-mutated NSCLC, nondisruptive TP53 mutations (associated with partial LOF and GOF) independently predicted shorter OS (17.8 vs. 28.4 months),114 highlighting the requirement for TP53 mutation stratification by functional class in KRAS-mutated contexts. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.