CD8A and neoplasm: Several key markers were assessed: HIF‐1α and GLUT1 to evaluate tumor metabolic activity and hypoxic adaptation, TGF‐β to reflect tumor response to hypoxic stress, and immune cell markers (CD8a for cytotoxic T cells, CD11c for dendritic cells, CD20 for B cells, and TCF7 for immune stem cells) to assess immune infiltration.