After stroke, the BBB is disrupted which allows antigenic products derived from the brain, such as myelin oligodendrocyte glycoprotein (MOG), myelin basic protein (MBP) and myelin proteolipid protein (PLP), to leak across the damaged BBB into the periphery contributing to the infiltration of peripheral immune cells into the CNS (Lakhan et al., 2009). This evidence concerns the gene PLP1 and stroke disorder.