However, in our study we observed decreased expressionof BCL2 and MCL1 in HCC hepatocytes, which – accordingto analysis of the apoptosis regulatory network – maybe due both to reduced expression of proteins that activateBCL2 and MCL1 expression (such as NF-κB, SDF1, ERBB,IL-8; Fig. 1) and to increased expression of proteins thatsuppress BCL2 expression (Fig. 2). This evidence concerns the gene CXCL12 and hepatocellular carcinoma.