In addition, ourscRNA-seq analysis (Table S1) showed increased expressionof genes encoding pro-apoptotic proteins in tumor hepatocytes,such as BID – a BAX/BAK activator (Moyer et al.,2025) – and FADD (FAS-associated death domain protein),a key component of the extrinsic apoptotic pathway (Nagataet al., 2017; Kashyap et al., 2021). This evidence concerns the gene BAK1 and neoplasm.