Bycontrast, the matrix metalloproteinase gene MMP9, whichwas upregulated, is activated, according to ANDSystem, by five proteins (MEIN1, PPIA, TRIB3, CHK1, FEN1), theexpression of which was also increased in tumor hepatocytes.In addition, CDC20, FEN1, KLF5, and their target genesshowed increased expression. This evidence concerns the gene CHEK1 and neoplasm.