Third, in mice, IH was demonstrated to increase vascular cell production of matrix metalloproteinases (MMPs) and metalloproteinases, including ADAM‐17 and the elastases MMP2 and MMP9, resulting in alteration of elastin in the aortic wall and the development of aortic aneurysms [59]. The gene discussed is ELN; the disease is aortic aneurysm.