GCG and Hyperglycemia: Our ex vivo data, using GLP-2 concentrations approximately 5 times higher than our clinical study, showed no GLP-2–induced glucagon secretion from isolated human islets exposed to glucose concentrations reflecting hypoglycemia, euglycemia, and hyperglycemia, respectively, suggesting no direct glucagonotropic effect of GLP-2 on human α cells, at least under the specific, tested experimental conditions.