We focused on the DIPG model IUE-24-C5 (PdgfraD842V, dominant negative Trp53, H3 WT),32 the DMG model IUE-K27M-APP (H3K27M, Trp53-Atrx-knockdown, PDGFRA-overexpression),30,34 and the medulloblastoma models SHH57835 (Ptch1+/−, Trp53 loss) and 7444 (c-Myc CRISPR, Trp53 loss, Cdkn2c loss).33 Here, APP is linked to medulloblastoma.