Aluminum (Al) is a well-known neurotoxin that plays a key role in AD onset and progression.4 It primarily accumulated in the frontal cortex and hippocampus, brain regions principally susceptible to AD.5 Prolonged Al exposure can result in neurochemical, neurobehavioral and neuropathological alterations, which hinder the learning capability in various animal studies.6–8 Moreover, Al persuades cytoskeleton proteins misfolding, leading to tau neurofibrillary tangles and amyloid beta plaques formation in the brain.9 Here, MAPT is linked to Alzheimer disease.