MAPT and memory impairment: Additionally, GSK-3β is a crucial kinase for tau phosphorylation, and its overactivation is closely related to plaque-associated microglial-mediated inflammatory responses, tau hyperphosphorylation, Aβ deposition, and memory impairment.24,26 Thus, the production of Aβ is eliminated when the BACE1 gene is deleted in the germline.