Nonetheless, there are three key histopathological hallmarks for AD including the building-up of hyper-phosphorylated tau protein inside the neurons, the accumulation of the incorrectly cleaved β-amyloid protein (Aβ) in the brain that then clusters together forming the senile plaques extracellularly between neurons, and finally synapses and neurons loss.3 The gene discussed is MAPT; the disease is Alzheimer disease.