In BISC, higher IL-6 levels were associated with recurrent MACE and stroke in those whose index event was of undetermined cause (IL-6, MACE: RR 1.78, 95% CI 1.19-2.66; IL-6, recurrent stroke: RR 1.65, 95% CI 1.09–2.5; CRP, MACE: RR 1.45, 95%CI 1.04–2.03) (ESOC, 2023). The gene discussed is IL6; the disease is stroke disorder.