E2F1 and Familial prostate cancer: To assess the reproducibility and biological relevance of the E2F1 binding sites identified in SETD6 WT DU145 cells, we compared our findings with published E2F1-ChIP-seq datasets derived from other prostate cancer cells (dataset SRR951091 taken from GSE49832 [45] and dataset SRR24060765 taken from GSE228895 [46]).