Finding: Ferroptosis in cerebral infarction is driven by glutathione depletion, glutathione peroxidase‐4 (GPX4) inactivation, and iron‐catalyzed lipid peroxidation of polyunsaturated phospholipids, with acyl‐CoA synthetase long‐chain family member‐4 (ACSL4) and lysophosphatidylcholine acyltransferase‐3 (LPCAT3) priming membranes for oxidative injury. The gene discussed is GPX4; the disease is brain infarction.