Additionally, GEFs (Ect2, Vav3, and Arhgef2), GAPs (Racgap1 and RhoJ) [42], and effectors (Pak3, Rtkn, and Iqgap3) are often overexpressed in HCC [45, 47, 49, 60]. Here, ARHGEF2 is linked to hepatocellular carcinoma.