Additionally, the underlying molecular mechanism of Klotho effect on hPDLSCs under the inflammatory environment was investigated.<h4>Results</h4>Ferroptosis was activated and the expression of Klotho was reduced in hPDLSCs under LPS-stimulated inflammatory environment, consistent with the results in hPDLSCs of periodontitis via single-cell RNA sequencing. Here, KL is linked to periodontitis.