These compounds formed strong interactions with essential amino acid residues in the CDK6 active site, suggesting a strong potential for inhibiting CDK6 activity.<h4>Conclusion</h4>These findings warrant further exploration of C. macropunctatus extract as a promising anti-cancer agent, with a focus on elucidating its role of CDK6 inhibition and its antiproliferative effects. The gene discussed is CDK6; the disease is cancer.