It has been reported that cholesterol efflux and esterification affect the formation of tumor cells.25 For example, cholesteryl ester accumulation induced by PTEN loss and PI3K/AKT activation underlies human prostate cancer aggressiveness.26 Even plasma cholesterol may serve as a biomarker to distinguish cancerous from precancerous stages. The gene discussed is PTEN; the disease is Familial prostate cancer.