CSNK1A1 and Bloom syndrome: As shown in Figs. 6B–G and S20A–C, the levels of β-catenin protein, pulmonary dysfunction, fibrosis areas, collagen fibrils, and hydroxyproline concentration were significantly reduced in Snx3-cKO mice compared with BLM mice, but AAV6-CK-1α reversed this lung-protective effect of SNX3 deficiency, as was also observed in AT2 cells (Figs. 6H–I and S20D–H).