To study the role of SNX3 in PF, a AT2 cells specific Snx3-cKO mouse model was produced by mating Snx3-floxed mice with the C57BL/6J Smoc-Sftpcem(IRES-CreERT2)Smoc mouse line and given tamoxifen to induce CreERT2 recombinase expression, and a PF mouse model was established via intratracheal injections of BLM (Fig. 2 and Fig. S4A–E). Here, SNX3 is linked to pemphigus foliaceus.