AHR and infection: Accordingly, dysregulated AHR activity can contribute to chronic inflammation, impaired barrier function, and even tumorigenesis.46,53,63,252,259,277,279,280 Owing to its central role in maintaining barrier homeostasis, AHR has emerged as a promising therapeutic target for a variety of conditions associated with barrier dysfunction, including autoimmune and inflammatory disorders and infection.252,281,282,284–286