In conclusion, AHR plays a pivotal role in development (Fig. 4) by engaging with key molecular pathways such as the Wnt/β-catenin, Notch, and transforming growth factor-β pathways, enabling it to influence cell fate decisions and differentiation in a context-dependent manner.225 At the transcriptional level, AHR governs the expression of genes critical for developmental processes and cancer progression.226,227 Given its broad regulatory functions, AHR is a crucial factor in cellular differentiation, organogenesis, and tissue homeostasis from early embryonic stages to adulthood. This evidence concerns the gene AHR and cancer.