To explore the potential mechanisms underlying BPNT1 overexpression in TNBC, we first assessed copy number amplification status of BPNT1 in breast cancer using The Cancer Genome Atlas Breast Cancer (TCGA-BRCA) dataset, and found that the amplification frequency of BPNT1 gene copy number was 5.8% in TNBC (Supplementary Fig. S2). Here, BPNT1 is linked to breast cancer.