Given the limited efficacy and the development of resistance to EGFR-TKIs, we performed compound library screening on PC9 (EGFR exon 19 ELREA-Del) and NCI-H1975 (EGFR L858R/T790M) cell lines to identify potential targets in EGFR-mutant NSCLC. Here, EGFR is linked to non-small cell lung carcinoma.