As TBL1X/TBL1XR1 expression levels were diminished in carotid arteries from patients with advanced unstable plaques compared to stable plaques or healthy controls, these data suggest that aberrant inhibition of TBL1X/TBL1XR1 in CD4<sup>+</sup> T cells may contribute to the development of atherosclerosis in humans. Here, TBL1XR1 is linked to atherosclerosis.