GATA1 and hypertensive disorder: Initial observations from another Brazilian study reported an association between the C allele and COVID-19 severity, in which the Duffy null allele, hypertension, and age were independently associated with the need for hospitalization.(18) The (-67T>C) variant in the 5’UTR region ofACKR1, where a T>C nucleotide substitution occurs, impairs promoter activity in erythrocytes by disrupting the binding of erythrocyte transcription factor GATA1.