CXCL8 and acute respiratory distress syndrome: The rs4073 (-251A>T) upstream variant ofCXCL8is located in the promoter region of the gene in an area with histone marks linked to transcriptional activation, such as H3K4me1, which potentially affects gene transcription levels.(38) The A allele is associated with higher systemic IL-8 levels in patients with ARDS.(39) Additionally, the AA genotype (-251A>T) has been linked to increasedCXCL6expression (eQTL — expression quantitative trait loci) in visceral adipose tissue, pancreas, and cultured fibroblast cells.(40)