Genes such as MAPK8IP2, which codes for the JIP2 protein (Roessler et al. 2018; Capilla-López et al. 2025), and REST (Khera et al. 2025) play roles in modulating neuronal stress responses, axonal transport, and synaptic homeostasis; their dysregulation have been reported to lead to early synaptic loss and impaired neuro-regenerative capability in AD (Cai and Tammineni 2017; Meftah and Gan 2023). Here, MAPK8IP2 is linked to Alzheimer disease.