These terms do not only encompass a greater range of neuron apoptosis regulation and calcium ion transport pathways, whose dysregulation are pivotal to the pathophysiology of AD (Ge et al. 2022; Goel et al. 2022), they also specify particular mechanisms of apoptosis; for example, GO:0042771, GO:0072332, and GO:1,902,253 are three biological processes enriched pointing specifically to the intrinsic apoptotic signalling pathway by p53 class mediator. Here, TP53 is linked to Alzheimer disease.