Moreover, numerous gene loci associated with DE transcripts found exclusively in the ML-filtered data were key contributors to the enrichment of GO terms highly relevant to AD (ANGPT1, CD44, CX3CR1, HHIP, LPAR4, MAPK8IP2, NAE1, PCDHGB4, PLP1, PROX1, REST, RYR2, SESTD1). This evidence concerns the gene PLP1 and Alzheimer disease.