AD pathogenesis is driven by a number of interrelated mechanisms, the most prominent ones being amyloid-β (Aβ) dysregulation (Murphy and LeVine 2010), disruptions in tau-associated cytoskeletal processes (Jiang et al. 2025), chronic neuroinflammation (Lecca et al. 2022), early synaptic dysfunction (Pelucchi et al. 2022), and impairments in lipid metabolism (Yin 2023) and endosomal–lysosomal trafficking (Szabo et al. 2022). The gene discussed is MAPT; the disease is Alzheimer disease.