Moreover, numerous gene loci associated with DE transcripts found exclusively in the ML-filtered data were key contributors to the enrichment of GO terms highly relevant to AD (ANGPT1, CD44, CX3CR1, HHIP, LPAR4, MAPK8IP2, NAE1, PCDHGB4, PLP1, PROX1, REST, RYR2, SESTD1). Here, RYR2 is linked to Alzheimer disease.