Moreover, numerous gene loci associated with DE transcripts found exclusively in the ML-filtered data were key contributors to the enrichment of GO terms highly relevant to AD (ANGPT1, CD44, CX3CR1, HHIP, LPAR4, MAPK8IP2, NAE1, PCDHGB4, PLP1, PROX1, REST, RYR2, SESTD1). The gene discussed is NAE1; the disease is Alzheimer disease.