MAPT and Alzheimer disease: Similarly, GO terms found to relate with cytoskeletal and centrosomal regulation, including microtubule organizing center organization (Li et al. 2007) and centrosome cycle (Granic and Potter 2013), are documented to cause disturbances in tau phosphorylation and microtubule stability observed in AD (Lovestone et al. 1996; Cyske et al. 2023).