PLP1 and Alzheimer disease: Other loci, PLP1 (Tatar et al. 2010) and PROX1 (Gazestani et al. 2023), relate to oligodendrocyte function, myelination, and neuronal circuit maintenance, support existing literature on white matter damage and loss of myelin starting early in AD (Depp et al. 2023; Huang et al. 2024).