RYR2 and Alzheimer disease: RYR2 (Yao et al. 2022) and SESTD1 (Beech 2012), are implicated in calcium release and membrane signalling dynamics, which fits earlier findings showing disrupted calcium balance leads to synapse issues and increased neuron-related risk in AD (Supnet and Bezprozvanny 2010; Guan et al. 2021).