Similarly, young bone marrow transplantation was capable of reversing the cerebral Aβ plaque burden, neuronal degeneration, neuroinflammation, and behavioral deficits in aged APP/PS1 mice (Sun et al., 2024b), revealing a potential central TRIM feature of the bone marrow in AD and their critical role in the development and progression of pathology. The gene discussed is TRAT1; the disease is Alzheimer disease.