Promoter identification; enhancer identification; silencer identification; insulator prediction; TF binding site prediction; chromatin accessibility prediction; histone mark presence; 5 mC/5 hmC site detection; PAS recognition; TIS recognition; splice donor/acceptor site identification; CRISPR-Cas guide efficiency; variant deleteriousness classification; COVID-19 variant classification; species/lineage classification. The gene discussed is TF; the disease is COVID-19.