FOXP3 and immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome: They play an indispensable role in maintaining immunological self‐tolerance and preventing excessive immune reactions that could damage the host.[11] In healthy individuals, Tregs typically constitute ≈5–10% of peripheral CD4+ T cells.[11] The importance of Tregs is underscored by rare disorders like IPEX syndrome, caused by mutations in the Treg‐defining gene FOXP3.