To determine whether CS‐NAC‐NPs protect articular cartilage by regulating GPX4‐mediated ferroptosis in chondrocytes, we generated cartilage‐specific GPX4 knockout (GPX4cKO) mice and induced osteoarthritis using the destabilization of the medial meniscus (DMM) model, followed by intraarticular injection of CS‐NAC‐NPs (Figure 7A). This evidence concerns the gene GPX4 and osteoarthritis.