CD274 and intrahepatic cholangiocarcinoma: Our experience suggests a pragmatic framework for selected patients with oligometastatic ICC presenting with a solitary brain lesion: (i) pursue surgical resection when feasible to achieve immediate mass control and obtain tissue, (ii) apply CGP to the metastatic specimen to uncover biomarkers, such as TMB-High or microsatellite instability-high, and (iii) integrate biomarker-guided systemic therapy (gemcitabine/cisplatin with PD-L1 blockade per TOPAZ-1)15) while considering maintenance ICI in responders.