Furthermore, the associations with the greatest functional impact determined by Ensembl Variant Effect Predictor (VEP)30 in ME/CFS included rs1047891 (MAF 31.2%), a missense variant of CPS1 with glycine (β = −0.62, p = 1.93 × 10−40), and rs174535 (MAF 35.1%), a synonymous variant of MYRF with sphingomyelin (β = 0.06, p = 3.07 × 10−12). Here, MYRF is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.